Resveratrol,Polygonum Cuspidatum P.E.,Polygonum Cuspidatum Extract

Specifications

[Product name] Resveratrol,Polygonum Cuspidatum P.E.,Polygonum Cuspidatum Extract[Latin Name] Polygonum Cuspidatum Sieb. et Zucc[Plant Source] Rhizome & Root of Giant Knotweed digged from China

[Specifications] Resveratrol 50%, 95%, 98% by HPLC

[Appearance] Brown or white fine powder

[Particle size] 100 Mesh

[Loss on drying] ≤ 5.0%

[Heavy Metal] ≤10PPM

[Extract solvents] Ethanol

[GMO Statement] GMO Free

[Microbe] Total Aerobic Plate Count: ≤1000CFU/G

Yeast & Mold: ≤100 CFU/G

[Characteristics]

1.Our resveratrol is 100% extracted from natural herb, very safe and more bioactive, which is rich with both CIS-resveratrol and trans-resveratrol.

2.Our resveratrol almost have no unpleasant taste compare to other resveratrols and it can be easier

to take by oral.

3..We offer resveratrol at a very competitive price with superb quality.

4. We have a very large output and could manufacturer as customer particular requirement.

Cardiovascular Effects
 Many studies suggest that consuming alcohol (especially red wine) may reduce the incidence of coronary heart disease (CHD). Several studies have demonstrated that resveratrol is an effective antioxidant. It inhibits lipid peroxidation of low-density lipoprotein (LDL), prevents the cytotoxicity of oxidized LDL, and protects cells against lipid peroxidation.

 It is thought that because it contains highly hydrophilic and lipophilic properties, it can provide more effective protection than other well-known antioxidants, such as vitamins C and E. On the other hand, it is less effective than the antioxidants quercetin and epicatechin found in red wine. Reduced platelet aggregation has also been demonstrated in studies on resveratrol, further contributing to its prevention of atherosclerosis.

Cancer-Related Effects
Resveratrol is being studied to see how it affects the initiation, promotion, and progression of cancer. With regard to tumor initiation, it has been shown to act as an antioxidant by inhibiting free radical formation, and as an anti-mutagen in rat models. Resveratrol appears to decrease tumor promotion activity by inhibiting cyclooxygenase-1 (COX-1), an enzyme that converts arachidonic acid to pro-inflammatory substances that stimulate tumor-cell growth .

Direct Antioxidant Activity
In the test tube, resveratrol effectively scavenges free radicals and other oxidants and inhibits low density lipoprotein (LDL) oxidation . However, there is little evidence that resveratrol is an important antioxidant in vivo . After oral consumption of resveratrol, circulating and intracellular levels of resveratrol in humans are likely to be much lower than that of other important antioxidants, such as vitamin C, vitamin E and glutathione. Moreover, the antioxidant activity of resveratrol metabolites, which comprise most of the circulating resveratrol, may be lower than that of resveratrol.

Inhibition of Vascular Smooth Muscle Cell Proliferation
The proliferation of vascular smooth muscle cells plays an important role in the progression of atherosclerosis . Resveratrol has been found to inhibit the proliferation of vascular smooth muscle cells in culture .

Inhibition of Platelet Aggregation
Platelet aggregation is one of the first steps in the formation of a blood clot that can occlude a coronary or cerebral artery, resulting in myocardial infarction or stroke. Resveratrol has been found to inhibit platelet aggregation in vitro.

Safety & Adverse Effects
Resveratrol is not known to be toxic or cause adverse effects in humans, but there have been few controlled clinical trials. In rats, daily oral administration of trans-resveratrol at doses up to 300 mg/kg of body weight for 4 weeks resulted in no apparent adverse effects .

Pregnancy and Lactation
The safety of resveratrol-containing supplements during pregnancy and lactation has not been established. Since no safe level of alcohol consumption has been established at any stage of pregnancy, pregnant women should avoid consuming wine as a source of resveratrol.

Estrogen-sensitive Cancers
Until more is known about the estrogenic activity of resveratrol in humans, women with a history of estrogen-sensitive cancers, such as breast, ovarian and uterine cancers, should avoid resveratrol supplements.

 Storage: Store in cool and dry place and avoid light and heat.
Shelf Life: 2 years